Document Type
Patent
Publication Date
February 2018
Patent Number
9896668
Abstract
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide and non-peptide compounds capable of binding to Akt. The non-peptide compounds show increased stability and rigidity compared to peptide counterparts and are less susceptible to degradation. The bound non-peptide compounds exhibit an inhibitory effect on Akt, similar to peptide-based Akt inhibitors.
Application Number
15/251572
Recommended Citation
Sebti, Said M.; Cheng, Jin Q.; Hamilton, Andrew D.; and Kayser-Bricker, Katherine, "Substrate-mimetic AKT inhibitor" (2018). USF Patents. 961.
https://digitalcommons.usf.edu/usf_patents/961
Assignees
University of South Florida
Filing Date
08/30/2016
