G01N 33/5058 (20130101)
This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.
Achyuta, Anilkumar H.; Cuevas, Javier; Sundaram, Shivshankar; and Katnik, Chris, "Microfluidic device for generating neural cells to simulate post-stroke conditions" (2017). USF Patents. 924.
University of South Florida