C12Q 1/6886 (20130101)
Methods of diagnosing large granular lymphocytic leukemia are provided herein. Novel splice variants of Granzyme B and Granzyme H as well as methods for screening for compositions regulating the splice variants and the development of therapeutic agents for the modulation thereof are also provided herein. Regulation of the splice variants is useful in the treatment of leukemic LGL, where these isoforms are constitutively over-expressed.
Loughran, Thomas P. Jr. and Kothapalli, Ravi, "Method of diagnosing large granular lymphocyte leukemia using alternative splice variants of serine proteases" (2016). USF Patents. 869.
University of South Florida