Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a Î³-lactam, in which an Î±-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular Câ€”H insertion, for example in the presence of a rhodium salt such as Rhby which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.
Jung, Kyung Woon and Yoon, Cheol Hwan, "Efficient lactam synthesis" (2004). USF Patents. 744.
University of South Florida