The present invention provides a method and apparatus adapted to facilitate the entry of a preselected molecule into the intracellular space of a cellular sample through the use of ions generated by a corona charge source. With the present method and apparatus, molecules are manipulated within cells and in the extracellular space surrounding the cells. Manipulation enhances the permeability of cell barriers to allow the subsequent introduction of molecules of interest into the interior of a cell.
Hoff, Drew; Jaroszeski, Mark J.; Gilbert, Richard; and Heller, Richard, "Corona ion generating method and apparatus for the manipulation of molecules and biological cells" (2005). USF Patents. 712.
University of South Florida