The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.
Tan, Jun; Nikolic, William; and Hou, Huyan, "Generation of transgenic human soluble amyloid precursor protein alpha expressing mice" (2011). USF Patents. 427.
University of South Florida