Document Type
Patent
Publication Date
April 2011
Patent Number
7927613
Abstract
A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.
Application Number
10/660,202
Recommended Citation
Almarsson, Örn; Bourghol Hickey, Magali; Peterson, Matthew L.; Zaworotko, Michael J.; Moulton, Brian; and Rodriguez-Hornedo, Nair, "Pharmaceutical co-crystal compositions" (2011). USF Patents. 389.
https://digitalcommons.usf.edu/usf_patents/389
Assignees
University of South Florida
Filing Date
09/11/2003
Primary/U.S. Class
424/400
