Document Type
Patent
Publication Date
February 2011
Patent Number
7892553
Abstract
The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density lipoprotein (LDL), attached to the core. The invention also concerns methods for reducing LDL cholesterol in a human or animal subject by administering nanoparticles of the invention. In a preferred embodiment, both circulating LDL and plasma cholesterol levels are reduced in the subject.
Application Number
11/799,367
Recommended Citation
Mohapatra, Shyam S. and Kumar, Arun, "Materials and methods to reduce low density lipoprotein cholesterol" (2011). USF Patents. 382.
https://digitalcommons.usf.edu/usf_patents/382
Assignees
University of South Florida
Filing Date
04/30/2007
Primary/U.S. Class
424/172
