Document Type
Patent
Publication Date
August 2012
Patent Number
8236853
Abstract
Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereoselective nature of the palladium catalyzed transformations.
Application Number
12/327,410
Recommended Citation
Bisht, Kirpal S.; Khan, Pasha M.; van Olphen, Alberto; and Wu, Ruizhi, "Formation of cyclopentene nitro-ester and derivatives" (2012). USF Patents. 343.
https://digitalcommons.usf.edu/usf_patents/343
Assignees
University of South Florida
Filing Date
12/03/2008
Primary/U.S. Class
514/546
