Document Type

Patent

Publication Date

December 2013

Patent Number

8598511

Abstract

This invention enables a sensitivity enhancement in the detection of molecular compounds. A mass spectrometry analyte support with nanotube anchors are used to concentrate MALDI samples, specifically samples prepared with water-insoluble matrix compounds, on the anchor spot. The surface structure is established through patterned carbon nanotube anchor growth, providing a nucleation center for analyte and reducing sample precipitation on the surrounding MALDI wafer. Also disclosed is a method of creating a mass spectrometry support using patterned metal catalyst to grow carbon nanotubes. The carbon nanotubes enhance nucleation on specific areas of a sample plate to concentrate analyte/matrix deposit during droplet evaporation.

Application Number

12/398,710

Assignees

University of South Florida

Filing Date

03/05/2009

Primary/U.S. Class

250/282

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