Document Type
Patent
Publication Date
October 2013
Patent Number
8551713
Abstract
The present invention relates to a series of markers and a method of determining cause of death post-mortem by quantifying thymus integrity. An examination of thymuses from human infants suffering mortal head trauma revealed a disruption of the cortical-medullary organization of the thymus, particularly involving dissolution of the cortical-medullary border. A similar result was obtained for related mouse and rat models. The human thymuses from head trauma cases also displayed a higher percentage of Ki67-positive thymocytes.
Application Number
13/295,684
Recommended Citation
Blanck, George and Lloyd, Mark, "Method for quantitative assessment of thymus integrity" (2013). USF Patents. 247.
https://digitalcommons.usf.edu/usf_patents/247
Assignees
University of South Florida H. Lee Moffitt Cancer Center and Research Institute, Inc.
Filing Date
11/14/2011
Primary/U.S. Class
435/71
