A61K 31/39(20130101), A61K 31/53(20130101)
The subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject invention also concerns methods for inducing apoptosis and inhibiting the proliferation or survival of a cell. In one embodiment, the methods comprise administering an effective amount of an agent or compound that inhibits the activity of one or more glucose transporter proteins, such as Glut-1. An antibody that binds to and inhibits a glucose transporter protein can be used in the present methods.
Simon, George R., "Oncotherapeutic application of inhibitors of high-affinity glucose transporters" (2015). USF Patents. 13.
University of South Florida