A61P 17/02, A61K 9/0019, A61K 9/005, A61K 9/006, A61K 31/047
Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.
D'Agostino, Dominic Paul and Kesl, Shannon, "Metabolic therapy for wound healing" (2020). USF Patents. 1219.
University of South Florida