Document Type
Article
Publication Date
December 2020
Patent Number
10864184
CPC
A61P 17/02, A61K 9/0019, A61K 9/005, A61K 9/006, A61K 31/047
Abstract
Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.
Application Number
14/554172
Recommended Citation
D'Agostino, Dominic Paul and Kesl, Shannon, "Metabolic therapy for wound healing" (2020). USF Patents. 1219.
https://digitalcommons.usf.edu/usf_patents/1219
Assignees
University of South Florida
Filing Date
11/26/2014
