Document Type
Patent
Publication Date
March 2015
Patent Number
8993760
CPC
C07D 401/04(20130101), C07D 217/02(20130101), C07D 241/08(20130101), C07D 401/06(20130101), C07D 401/12(20130101)
Abstract
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death.
Application Number
12/488,826
Recommended Citation
Sebti, Said M. and Hamilton, Andrew D., "Rock inhibitors and uses thereof" (2015). USF Patents. 12.
https://digitalcommons.usf.edu/usf_patents/12
Assignees
University of South Florida
Filing Date
06/22/2009
