G01N 2291/02466, G01N 2291/02475, G01N 29/022, G01N 29/036, G01N 29/222, G01N 29/2462, G01N 33/48, G10K 11/36, H03H 9/0009, H03H 9/145, H03H 9/14502, H03H 9/25, H03H 2009/0019
A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.
Mohapatra, Shyam S.; Mohapatra, Subhra; Guldiken, Rasim Oytun; Nair, Rajesh R.; and Wang, Tao, "System and method of measuring cell viability and growth" (2019). USF Patents. 1116.
University of South Florida