The present invention is directed to a novel class of antimicrobial agents called Î³-AApeptides. The current invention provides various categories of Î³-AApeptides, for example, linear Î³-AApeptides, cyclic Î³-AApeptides, and lipidated Î³-AApeptides. Î³-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. Î³-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed Î³-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
Cai, Jianfeng; Niu, Youhong; Wu, Haifan; and Padhee, Shruti, "Î³-AApeptides with potent and broad-spectrum antimicrobial activity" (2018). USF Patents. 1094.
University of South Florida