Title

Glutathione Levels in Olfactory and Non Olfactory Neural Structures of Rats

Document Type

Article

Publication Date

1991

Keywords

Glutathione, Brain, Olfactory epithelium, Olfactory bulb, Development, Aging

Digital Object Identifier (DOI)

https://doi.org/10.1016/0006-8993(91)90047-Y

Abstract

Olfactory receptor neurons are a CNS entry point for a wide variety of airborne substances. Therefore, it is probable that detoxification mechanisms are present in these neurons to neutralize such agents. Glutathione (GSH) is an essential component of several detoxification schemes, and this study we examined the distribution and levels of GSH in the olfactory epithelium, olfactory bulb, cortex, hippocampus and cerebellum in neonatal, weanling, adult and aged rats. We report that GSH is primarily localized to the olfactory receptor neurons and their axons within the olfactory epithelium. It is also localized within the glomerular neuropil and granule cells of the olfactory bulb. Levels of GSH in the olfactory epithelium and hippocampus do not change as a function of age, although GSH levels decrease in several brain regions, including the olfactory bulb, cerebellum and cortex.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

Brain Research, v. 543, issue 2, p. 341-346

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