Title

Animal Models in Translational Studies of PTSD

Document Type

Article

Publication Date

9-2013

Keywords

Post-traumatic stress disorder, PTSD, Animal model, Translational Biomarkers, Therapeutics, Individual differences

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.psyneuen.2013.06.006

Abstract

Understanding the neurobiological mechanisms of post-traumatic stress disorder (PTSD) is of vital importance for developing biomarkers and more effective pharmacotherapy for this disorder. The design of bidirectional translational studies addressing all facets of PTSD is needed. Animal models of PTSD are needed not only to capture the complexity of PTSD behavioral characteristics, but also to address experimentally the influence of variety of factors which might determine an individual's vulnerability or resilience to trauma, e.g., genetic predisposition, early-life experience and social support. The current review covers recent translational approaches to bridge the gap between human and animal PTSD research and to create a framework for discovery of biomarkers and novel therapeutics.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Psychoneuroendocrinology, v. 38, issue 9, p. 1895-1911

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