Animal Models in Translational Studies of PTSD
Document Type
Article
Publication Date
9-2013
Keywords
Post-traumatic stress disorder, PTSD, Animal model, Translational Biomarkers, Therapeutics, Individual differences
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.psyneuen.2013.06.006
Abstract
Understanding the neurobiological mechanisms of post-traumatic stress disorder (PTSD) is of vital importance for developing biomarkers and more effective pharmacotherapy for this disorder. The design of bidirectional translational studies addressing all facets of PTSD is needed. Animal models of PTSD are needed not only to capture the complexity of PTSD behavioral characteristics, but also to address experimentally the influence of variety of factors which might determine an individual's vulnerability or resilience to trauma, e.g., genetic predisposition, early-life experience and social support. The current review covers recent translational approaches to bridge the gap between human and animal PTSD research and to create a framework for discovery of biomarkers and novel therapeutics.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Psychoneuroendocrinology, v. 38, issue 9, p. 1895-1911
Scholar Commons Citation
Deskalakis, Nikolaos P.; Yehuda, Rachel; and Diamond, David M., "Animal Models in Translational Studies of PTSD" (2013). Psychology Faculty Publications. 1376.
https://digitalcommons.usf.edu/psy_facpub/1376
