Title

Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

Document Type

Article

Publication Date

10-2010

Keywords

antidepressant, synaptic plasticity, memory, animal model, glutamate, stress

Digital Object Identifier (DOI)

https://doi.org/10.3390/ph3103143

Abstract

Tianeptine is a well-described antidepressant which has been shown to prevent stress from producing deleterious effects on brain structure and function. Preclinical studies have shown that tianeptine blocks stress-induced alterations of neuronal morphology and synaptic plasticity. Moreover, tianeptine prevents stress from impairing learning and memory, and, importantly, demonstrates memory-enhancing properties in the absence of stress. Recent research has indicated that tianeptine works by normalizing glutamatergic neurotransmission, a mechanism of action that may underlie its effectiveness as an antidepressant. These findings emphasize the value in focusing on the mechanisms of action of tianeptine, and specifically, the glutamatergic system, in the development of novel pharmacotherapeutic strategies in the treatment of depression.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Pharmaceuticals, v. 3, issue 10, p. 3143-3166

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