Title

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer’s Disease Model

Document Type

Article

Publication Date

2003

Keywords

APP/PS1 transgenic mice, Signaling, Cognitive behavior, Blueberry supplementation

Digital Object Identifier (DOI)

https://doi.org/10.1080/1028415031000111282

Abstract

Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report that BB-fed (from 4 months of age) APP+PS1 transgenic mice showed no deficits in Y-maze performance (at 12 months of age) with no alterations in amyloid beta burden. It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Nutritional Neuroscience, v. 6, issue 3, p. 153-162

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