Title

Cytochrome Oxidase Inhibition: A Novel Animal Model of Alzheimer's Disease

Document Type

Article

Publication Date

1992

Digital Object Identifier (DOI)

https://doi.org/10.1177%2F002383099200500206

Abstract

A profound decrease in activity of the mitochondrial enzyme cytochrome oxidase in blood platelets is a recently identified concomitant of Alzheimer's disease (AD). We investigated a possible pathogenic link between this finding and the symptoms of AD by mimicking this mitochondrial enzyme deficiency in rats. Rats were infused chronically with a selective inhibitor of cytochrome oxidase, sodium azide, or with saline delivered via subcutaneously implanted osmotic minipumps. The azide treatment impaired both spatial and nonspatial learning. Further, the azide treatment inhibited a low-threshold form of hippocampal long-term potentiation, primed burst potentiation. The behavioral deficits were not secondary to a sensory or motor impairment. Thus, chronic azide treatment of rats models some characteristics of AD.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

The Journal of Geriatric Psychiatry and Neurology, v. 5, issue 2, p. 93-101

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