Differential Sensitivity of Hippocampal Primed Burst Potentiation to Anesthetics
CA1, Long-term potentiation, Hippocampus, Urethane, Barbiturate, Corticosterone
Digital Object Identifier (DOI)
This study demonstrates that the anesthetics urethane and pentobarbital differentially affect a low threshold form of long-lasting synaptic plasticity, termed primed burst (PB) potentiation, in the CA1 area of rat hippocampus. PB potentiation was generated by the delivery of a 5-pulse patterned stimulus train, consisting of one priming pulse followed 170 ms later by a burst of 4 pulses at 200 Hz. PB potentiation could not be reliably generated in urethane-anesthetized rats unless stimulus currents were raised to 150% of baseline levels during the stimulus train. In pentobarbital-anesthetized rats, PB potentiation could always be evoked at baseline stimulus intensities. Differences between the anesthetics which could contribute to their varying effects upon PB potentiation are discussed.
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Citation / Publisher Attribution
Brain Research, v. 521, issue 1-2, p. 148-152
Scholar Commons Citation
Engstrom, David A.; Bennett, Catherine M.; Stevens, Karen E.; Wilson, Rebecca L.; Diamond, David M.; Fleshner, Monika; and Rose, Greg M., "Differential Sensitivity of Hippocampal Primed Burst Potentiation to Anesthetics" (1990). Psychology Faculty Publications. 1294.