Document Type
Article
Publication Date
2018
Keywords
chemistry, salt, water solubility, routes of administration, physicochemical, stability, degradation
Digital Object Identifier (DOI)
https://doi.org/10.3390/molecules23071719
Abstract
The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Molecules, v. 23, issue 7, art. 1719
Scholar Commons Citation
Gupta, Deepak; Bhatia, Deepak; Dave, Vivek; Sutariya, Vijaykumar B.; and Varghese Gupta, Sheeba, "Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations" (2018). Pharmacy Faculty Publications. 60.
https://digitalcommons.usf.edu/pharm_facpub/60
