Innovations in traffic signal systems have generated a great deal of interest in the provision of preferential traffic signal strategies and treatments for transit buses and other vehicles at signalized intersections in cities of all sizes. The primary objective of this paper is three fold: 1) to synthesize the literature of the lessons learned associated with planning and deploying transit signal priority (TSP) strategies in small and medium-sized cities; 2) to demonstrate the application of a micro-simulation model, VISSIM, to assess transit priority impacts in small and medium-sized communities where the required VISSIM input data are often limited; and 3) to present guidelines to aid traffic engineers and transit planners who are considering TSP strategies in small and medium-sized cities. An underlying aim of this paper is to recognize the differences in transit priority planning and deployment in small and medium-sized cities as compared to major metropolitan areas.