Title

Cassia Auriculata: Aspects of Safety Pharmacology and Drug Interaction

Document Type

Article

Publication Date

6-22-2011

Digital Object Identifier (DOI)

https://doi.org/10.1093/ecam/nep237

Abstract

Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

Evidence-based Complementary and Alternative Medicine, v. 2011, art. 915240

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