Graduation Year
2013
Document Type
Dissertation
Degree
Ph.D.
Degree Granting Department
Chemistry
Major Professor
Peter Zhang
Keywords
asymmetric, azide, aziridination, catalysis, cobalt, porphyrin
Abstract
Asymmetric nitrene transfer reactions via metalloradical catalysis (MRC) with
azides has attracted research interest because of its fundamental and practical importance.
The resulting nitrogen-containing units are recurrent motifs in biologically important
molecules and can serve as versatile precursors in organic synthesis.
The [Co(D2-Por*)] have emerged as a new class of catalysts for asymmetric
aziridination and C-H amination. These metalloradical catalysts have been shown to be
highly effective for the asymmetric intermolecular aziridination of a broad scope of
substrates with different classes of azides with excellent to good enantioselectivity. The
intramolecular C-H amination utilizing various azides can allow for the construction of
diverse nitrogen containing heterocyclic compounds.
Scholar Commons Citation
Tao, Jingran, "Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC)" (2013). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/4590
