Graduation Year
2011
Document Type
Thesis
Degree
M.S.B.E.
Degree Granting Department
Chemical Engineering
Major Professor
Venkat Bhethanabotla, Ph.D.
Committee Member
Timothy J. Fawcett, Ph.D.
Committee Member
Robert Frisina Jr., Ph.D.
Keywords
Atrial Fibrillation, Cardiac Modeling, Atrial Electrograms, Ablation Model, Excitation Propagation, AF Modeling, Finite Element Modeling, Bidomain Modeling, Courtemanche Cell Model
Abstract
A finite-element model of a two-dimensional slice of human atrial tissue for the study of the electrograms and propagation of action potentials is presented. Action potential propagation is described by a reaction-diffusion model coupled with the complex Courtemanche et al. atrial cell model. The effects of recording electrode size and location on electrograms are presented. Action potential propagation as a result of atrial fibrillation ablation therapy is also modeled by defining a lesion area with decreased electrical conductivity. The effect of electrical conductivity and geometry of the lesion was also studied. It is shown that the success rate of atrial fibrillation ablation therapy is primarily correlated with the creation of continuous ablation lines and also the formation of fibrous tissue.
Scholar Commons Citation
Esfahani, Samineh R., "Two-Dimensional Computer Model of Human Atrial Ablation" (2011). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/3093
