Inflammation, Adiposity, and Progression of Arterial Stiffness in Adolescents with Type 1 Diabetes: The SEARCH CVD Study
Type 1 diabetes mellitus, Inflammation, Pulse wave analysis, Waist circumference, Arterial stiffness, Fibrinogen
Digital Object Identifier (DOI)
Methods: A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.
Results: PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants.
Conclusions: Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.
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Citation / Publisher Attribution
Journal of Diabetes and its Complications, v. 32, issue 11, p. 995-999
Scholar Commons Citation
Alman, Amy C.; Talton, Jennifer W.; Wadwa, R. P.; Urbina, Elaine M.; Dolan, Lawrence M.; Hamman, Richard F.; D'Agostino, Ralph B. Jr.; Marcovina, Santica M.; and Dabelea, Dana M., "Inflammation, Adiposity, and Progression of Arterial Stiffness in Adolescents with Type 1 Diabetes: The SEARCH CVD Study" (2018). Epidemiology and Biostatistics Faculty Publications. 7.