Quinoline, Antibacterial, Gram-positive, Clostridium difficile, In vivo
Digital Object Identifier (DOI)
Quinoline compounds have been extensively explored as anti-malaria and anti-cancer agents for decades and show profound functional bioactivities, however, the studies of these compounds in other medicinal fields have lagged dramatically. In this study, we report the development of a series of facilely accessible quinoline derivatives that display potent antibacterial activity against a panel of multidrug-resistant Gram-positive bacterial strains, especially C. difficile. We also demonstrated that these molecules are effective in vivo against C. difficile. These results revealed that these types of quinoline compounds could serve as prototypes for the development of an appealing class of antibiotic agents used to combat Gram-positive drug-resistant bacterial strains, including C. difficile.
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Citation / Publisher Attribution
Bioorganic & Medicinal Chemistry, v. 26, issue 12, p. 3573-3579
This article is the post-print author version. Final version available at: https://doi.org/10.1016/j.bmc.2018.05.031
Scholar Commons Citation
Teng, Peng; Li, Chunhui; Peng, Zhong; Vanderschouw, Anne Marie; Nimmagadda, Alekhya; Su, Ma; Li, Yaqiong; Sun, Xingmin; and Cai, Jianfeng, "Facilely Accessible Quinoline Derivatives as Potent Antibacterial Agents" (2018). Chemistry Faculty Publications. 60.