Title

Nano‐Sized Lipidated Dendrimers as Potent and Broad‐Spectrum Antibacterial Agents

Document Type

Article

Publication Date

12-2018

Keywords

amphipathic, asymmetric, dendrimers, host defense peptides, lipid tails

Digital Object Identifier (DOI)

https://doi.org/10.1002/marc.201800622

Abstract

There is considerable interest in the development of antimicrobial polymers including dendrimers due to the ease of synthesis and low manufacturing cost compared to host defense peptides (HDPs). Herein, a new class of nanomaterials—lipidated amphiphilic dendrimers—is presented that mimic the antibacterial mechanism of HDPs by compromising bacterial cell membranes. Unlike conventional dendrimers that are prepared generation by generation symmetrically with molecular weight distribution, these lipidated dendrimers are prepared on the solid phase with a hanging lipid tail and precisely controlled structure. It is shown through rational design that these lipidated dendrimers display potent and selective antimicrobial activity against both Gram‐positive and Gram‐negative bacteria, including multidrug‐resistant strains. In addition to antibacterial activity against planktonic bacteria, these dendrimers are also shown to inhibit bacterial biofilms effectively. This class of dendrimers as a new class of biomaterials may lead to a useful generation of antibiotic agents with practical applications.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Macromolecular Rapid Communications, v. 39, issue 24, art. 1800622

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