Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease
Digital Object Identifier (DOI)
Objectives: To compare the inflammatory reaction associated with the insertion of silicone and polypropylene endplates and endplates made of a new biocompatible polymer, Vivathane, in the rabbit subconjunctival space.
Methods: Similar-sized endplates made of 3 different biomaterials were sutured to the sclera in the superotemporal quadrant of the rabbit eye. Thirty eyes of 15 albino New Zealand rabbits were randomly assigned to the 3 groups. Conjunctival vascular hyperemia was graded in a masked fashion among groups. At the end of 3 weeks, the enucleated eyes were examined histologically and using scanning electron microscopy.
Results: Polypropylene and Vivathane were associated with significantly more inflammation in clinical observations and based on histological grading. Silicone was associated with the least amount of inflammation. Three polypropylene and 1 Vivathane plate were extruded between the second and third week.
Conclusions: Silicone is the most inert of the 3 materials tested. Inflammation associated with biomaterials may contribute to the failure of the glaucoma drainage devices.
Clinical Relevance: Bleb inflammation may be related to the biomaterial being used as the endplate. Endplates should be handled carefully during surgery to avoid creating rough spots.
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Citation / Publisher Attribution
Arch Ophthalmol, v. 117, issue 2, p. 233-236
Scholar Commons Citation
Ayyala, Ramesh S.; Harman, Lynn E.; Michelini-Norris, B; Ondrovic, Leo E.; Haller, Edward M.; Margo, Curtis E.; and Stevens, Scott X., "Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease" (1999). Integrative Biology Faculty and Staff Publications. 294.