Role of Deubiquitinating Enzymes in DNA Repair

Authors

Younghoon Kee, University of South FloridaFollow
Tony T. Huang, New York University School of Medicine

Document Type

Article

Publication Date

2-15-2016

Digital Object Identifier (DOI)

https://doi.org/10.1128/MCB.00847-15

Abstract

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.

Rights Information

Terms of use for work posted in Scholar Commons.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Molecular and Cellular Biology, v. 36, no. 4, p. 524-544

Kee Y, Huang TT. 2016. Role of deubiquitinating enzymes in DNA repair. Mol Cell Biol 36:524–544. https://doi.org/10.1128/MCB.00847-15.

Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Scholar Commons Citation

Kee, Younghoon and Huang, Tony T., "Role of Deubiquitinating Enzymes in DNA Repair" (2016). Molecular Biosciences Faculty Publications. 30.
https://digitalcommons.usf.edu/bcm_facpub/30