The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
Baker, Bill; Diyabalanage, Thushara; McClintock, James B.; and Amsler, Charles D., "Cytotoxin compounds and methods of isolation" (2014). USF Patents. 93.
University of South Florida The UAB Research Foundation