Document Type
Patent
Publication Date
February 2014
Patent Number
8642278
Abstract
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.
Application Number
11/562,903
Recommended Citation
Sebti, Said M.; Chellappan, Srikumar; and Lawrence, Nicholas James, "Inhibition of cell proliferation" (2014). USF Patents. 86.
https://digitalcommons.usf.edu/usf_patents/86
Assignees
University of South Florida
Filing Date
11/22/2006
Primary/U.S. Class
435/723
