Document Type
Patent
Publication Date
March 2004
Patent Number
6714816
Abstract
The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
Application Number
09/507,859
Recommended Citation
Heller, Richard; Gilbert, Richard; Jaroszeski, Mark J.; Heller, Loree C.; and Lucas, Melinda L., "Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo" (2004). USF Patents. 751.
https://digitalcommons.usf.edu/usf_patents/751
Assignees
University of South Florida
Filing Date
02/22/2000
Primary/U.S. Class
607/3
