SHIP-deficiency to increase megakaryocyte progenitor production

Authors

William G. Kerr
Caroline Desponts
Lia Elena Perez

Document Type

Patent

Publication Date

July 2010

Patent Number

7763592

Abstract

The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.

Application Number

11/451,004

Recommended Citation

Kerr, William G.; Desponts, Caroline; and Perez, Lia Elena, "SHIP-deficiency to increase megakaryocyte progenitor production" (2010). USF Patents. 505.
https://digitalcommons.usf.edu/usf_patents/505

Assignees

University of South Florida

Filing Date

06/12/2006

Primary/U.S. Class

514/44