Document Type
Patent
Publication Date
July 2012
Patent Number
8227434
Abstract
The subject invention pertains to materials and methods for treating oncological disorders. The subject invention also pertains to materials and methods for preventing or reducing the development by cancer cells of resistance to an anticancer therapy, such as chemotherapy, radiotherapy and/or immunotherapy. In one embodiment, a patient is treated with an agent that inhibits cholesterol synthesis or that prevents or reduces the increase in cholesterol synthesis observed in therapy-resistant cancer cells. In another embodiment, a patient is treated with an agent that increases the expression, activity, or amount of a Bim protein in a cell. In another embodiment, a patient is treated with an agent to inhibit or reduce cancer cell adhesion to extracellular matrices or stromal cells. In another embodiment, a patient is treated with an agent to inhibit expression of a gene of function of a protein of the FANC/BRCA pathway. In a further embodiment, a patient is treated with an agent to prevent or reduce the DNA crosslink repair function of a cell.
Application Number
10/983,009
Recommended Citation
Dalton, William S.; Hazlehurst, Lori; and Chen, Qing, "Materials and methods for treating oncological disorders" (2012). USF Patents. 339.
https://digitalcommons.usf.edu/usf_patents/339
Assignees
H. Lee Moffitt Cancer Center & Research Institute, Inc.
Filing Date
11/04/2004
Primary/U.S. Class
514/44A
