Document Type
Patent
Publication Date
April 2012
Patent Number
8163710
Abstract
Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP−/− which exhibits enhanced survival following mismatched allogeneic marrow grafts.
Application Number
12/651,809
Recommended Citation
Kerr, William G., "Reduction of graft-versus-host disease by modulation of SHIP activity" (2012). USF Patents. 316.
https://digitalcommons.usf.edu/usf_patents/316
Assignees
University of South Florida
Filing Date
01/04/2010
Primary/U.S. Class
514/44R
