This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylcoccus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.
Turos, Edward; Mishra, Rajesh Kumar; Revell, Kevin; and Coates, Cristina M., "Derivative N-thiolated 2-oxazolidinone antibiotics" (2014). USF Patents. 104.
University of South Florida