Title

Early Adolescents Show Enhanced Acute Cocaine Induced Locomotor Activity in Comparison to Late Adolescent and Adult Rats

Document Type

Article

Publication Date

3-2008

Keywords

Sprague–Dawley, adolescent rat, dopamine, limbic system, drug abuse

Digital Object Identifier (DOI)

https://doi.org/10.1002/dev.20252

Abstract

Initiation of drug use during adolescence is associated with an increased probability to develop a drug addiction. The present study examined dose–response effects of cocaine (0, 5, 10, or 20 mg/kg, i.p.) on locomotor activity in early adolescent (postnatal day (PND) 35), late adolescent (PND 45), and young adults (PND 60) by measuring total distance moved (TDM) and frequency of start–stops. In response to 20 mg/kg cocaine, early adolescents showed the greatest cocaine‐induced increase in TDM in comparison to late adolescent and adult rats. At this same dose, early adolescents showed the greatest cocaine‐induced attenuation of start–stops relative to older rats. Results suggest that early adolescents engage in more cocaine‐induced locomotor activity and less stationary behavior indicating that early adolescents are more sensitive to locomotor activating effects of high dose cocaine than older rats.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Developmental Psychobiology, v. 50, issue 2, p. 127-133

Share

COinS