Title

Effects of Excitotoxic Lesions of the Gustatory Thalamus on Latent Inhibition and Blocking of Conditioned Taste Aversion in rats.

Document Type

Article

Publication Date

12-15-2003

Keywords

Acetic Acid, Animals, Avoidance Learning, Conditioning, Classical, Lithium Chloride, Male, Neural Inhibition, Rats, Rats, Sprague-Dawley, Sodium Chloride, Sucrose, Taste, Thalamus

Digital Object Identifier (DOI)

http://dx.doi.org/10.1016/j.brainresbull.2003.08.009

Abstract

The influence of bilateral excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion (CTA) was examined in two experiments. In Experiment 1, rats with thalamic lesions showed normal latent inhibition by acquiring a CTA that was significantly weaker when the conditioned stimulus (CS) was familiar than when it was novel. In Experiment 2, the preconditioned element (sodium chloride) of a compound CS blocked the acquisition of a CTA to the novel element (sucrose) in normal rats. Irrespective of whether sodium chloride was preconditioned or not, rats with thalamic lesions showed little or no aversion to sucrose following compound conditioning. Overall, the results provide no support for the experimental hypothesis that thalamic lesions disrupt decremental changes in the attentional processing of gustatory stimuli.

Comments

Brain Research Bulletin, V. 62, Issue 2, P. 117-128.

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