Title

Two-Day Radial-Arm Water Maze Learning and Memory Task; Robust Resolution of Amyloid-related Memory Deficits in Transgenic Mice

Document Type

Article

Publication Date

11-9-2006

Digital Object Identifier (DOI)

https://doi.org/10.1038/nprot.2006.275

Abstract

The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Nature Protocols, v. 1, p.1671-1679

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