Title

Combination of High Fat Diet and Chronic Stress Retracts Hippocampal Dendrites

Document Type

Article

Publication Date

1-19-2005

Keywords

Atrophy, Brain, CA3, High fat diet, Hippocampus, Psychological stress, Synergy

Abstract

Adult male rats were fed a low or high fat diet and given psychosocial stress (crowded and unstable housing with daily predator exposure) for 3 weeks. Neither stress nor high fat diet, alone, produced dendritic atrophy; only the group given the combination of stress and high fat diet developed a reduction of the length and number of branch points of apical dendrites of CA3 neurons. These findings indicate that a synergy between high fat diet and stress caused a retraction of CA3 dendrites. The findings are consistent with work on peripheral (e.g., cardiovascular) systems demonstrating a synergy between stress and high fat diet, and are relevant toward understanding how diet and stress interact to adversely affect brain and memory processing.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

NeuroReport, v. 16, issue 1, p. 39-43

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