Title

High Calcium Intake Does not Prevent Stress-Salt Hypertension in Dogs

Document Type

Article

Publication Date

1986

Digital Object Identifier (DOI)

https://doi.org/10.1007/BF02995040

Abstract

Avoidance conditioning sessions and isotonic saline (1.3 L/day) were administered to dogs for 12 days under conditions of a low (0.1%) or high (1.5%) calcium diet. Twenty-four-hour mean arterial pressure increased comparably during the stress-salt conditioning periods on both the low (systolic: +16 ± 5 mm Hg; diastolic: +6 ± 2 mm Hg) and high (systolic: +17 ± 4 mm Hg; diastolic: +11 ± 4 mm Hg) calcium diets. Urine volume, sodium excretion, and serum calcium levels on the high calcium diet were not significantly different from those on the low calcium diet. In a second experiment, calcium was infused continuously for six days into the arterial circulation of normotensive or stress-salt hypertensive dogs at a rate of 0.12–0.23 mEq/min. Although serum calcium levels increased by up to 50% under these conditions, there were no significant effects on 24-hour levels of arterial pressure. In contrast to the protective effect of augmented potassium intake, these findings indicate that calcium intake does not influence the development of stress-salt hypertension in dogs.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

The Pavlovian Journal of Biological Science, v. 21, issue 1, p. 25-31