Guizhaphaenops zorzini n.gen.n.sp. is described from Anjia Yan Cave, Shuicheng County, Guizhou (China). This highly specialized troglobite species is easily recognizable from the other cave dwelling Trechini from China for the main morphological external characters, but its true relationships remain uncertain, the male being still unknown. Similar in habitus to Cathaiaphaenops and to Sinotroglodytes, the new taxon is much more related to the latter, being dorsally glabrous and having the mentum fused with the submentum, with a deep oval fovea, but it differs in its elongated head, with incomplete frontal furrows and without posterior frontal setae.