Graduation Year

2005

Document Type

Dissertation

Degree

Ph.D.

Degree Granting Department

Psychology

Major Professor

Paul R. Sanberg.

Co-Major Professor

Cheryl L. Kirstein

Keywords

Ischemic, Chemoattractants, Stroke, Transplantation, Stem cells

Abstract

Human umbilical cord blood (HUCB) cells consist of a heterogeneous population of cells, rich in hematopoietic stem and progenitor cells. These cells have been used in the treatment of various nonmalignant and malignant hematopoietic diseases. With in the last few years HUCB cells have been used in pre-clinical animal models of brain and spinal cord injuries, in which functional recovery has been shown. The properties of cord blood cells that could be important in cell transplantation (repair or replacement) of CNS injury or disease are currently being evaluated. The major focus of this study was to determine whether HUCB cells would migrate to ischemic tissue extracts. In addition, factors that may be inducing the cells to migrate were examined by identifying the cytokines or chemokines present in the ischemic tissue extracts.

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