MS in Materials Science and Engineering (M.S.M.S.E)
Degree Granting Department
Venkat Bhethanabotla, Ph.D.
John Kuhn, Ph.D.
Anna Pyayt, Ph.D.
Silver Nanocubes, CEA, Immunofluorescence, Biotechnology, Limit of Detection
In this paper, metal-enhanced fluorescence (MEF) technique is used to lower the detection limit of carcinoembryonic antigen (CEA) which is able to be utilized in forecasting the risk of having certain kinds of cancers, especially colon and rectal cancer. By incubating silver nanocubes (Ag NCs) on the surface of the chips, the detection limit goes down to below 1ng/mL of CEA. Also, when combining MEF with surface acoustic wave (SAW) devices, the incubation time between antigen and antibody will decrease significantly with the fluorescence signal keeping similar or higher level.
Scholar Commons Citation
Liu, Jun, "Biomarker Detection at Risk Forecasting Level Using Metal-Enhanced Fluorescence Combined with Surface Acoustic Wave" (2016). Graduate Theses and Dissertations.
Available for download on Wednesday, November 15, 2017