Master of Science (M.S.)
Degree Granting Department
Bill Baker, Ph.D.
Ed Turos, Ph.D.
Lindsey Shaw, Ph.D.
Wayne Guida, Ph.D.
cross-talk, diketopiperazine, Natural Products, secondary metabolites
New methodology has been utilized to provoke or increase targeted metabolic pathways
in microbes. The low hanging fruit of natural products has been discovered over the last 50
years. To continue finding new metabolites to be used as possible drug candidates, methodology
development such as those proposed herein are necessary. This methodology uses extracts from
known pathogenic bacteria to elicit production of latent biosynthetic pathways from
environmental bacterial isolates that may be active against the original pathogenic strains. A
new compound, MAV-1 (1) of the diketopiperazine family (Figure 1) was isolated and identified
utilizing these techniques. The structure of MAV-1 (1) was defined by a combination of mass
spectroscopy (MS) and nuclear magnetic resonance (NMR) spectroscopy. Discovery of MAV-1
(1), a possible precursor to other known compounds, demonstrates the continuing utility of
microbial sources with new chemodiversity.
Scholar Commons Citation
Veri, Michael, "Dead/Live Microbial Culture Technique" (2015). Graduate Theses and Dissertations.