Graduation Year

2015

Document Type

Thesis

Degree

M.S.

Degree Name

Master of Science (M.S.)

Department

Chemistry

Degree Granting Department

Chemistry

Major Professor

Bill Baker, Ph.D.

Committee Member

Ed Turos, Ph.D.

Committee Member

Lindsey Shaw, Ph.D.

Committee Member

Wayne Guida, Ph.D.

Keywords

cross-talk, diketopiperazine, Natural Products, secondary metabolites

Abstract

New methodology has been utilized to provoke or increase targeted metabolic pathways

in microbes. The low hanging fruit of natural products has been discovered over the last 50

years. To continue finding new metabolites to be used as possible drug candidates, methodology

development such as those proposed herein are necessary. This methodology uses extracts from

known pathogenic bacteria to elicit production of latent biosynthetic pathways from

environmental bacterial isolates that may be active against the original pathogenic strains. A

new compound, MAV-1 (1) of the diketopiperazine family (Figure 1) was isolated and identified

utilizing these techniques. The structure of MAV-1 (1) was defined by a combination of mass

spectroscopy (MS) and nuclear magnetic resonance (NMR) spectroscopy. Discovery of MAV-1

(1), a possible precursor to other known compounds, demonstrates the continuing utility of

microbial sources with new chemodiversity.

Included in

Chemistry Commons

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